Discrimination of regulatory DNA by SVM on the basis of over- and under-represented motifs

نویسندگان

  • I. René J. A. te Boekhorst
  • Irina I. Abnizova
  • Lorenz Wernisch
چکیده

In this paper we apply three pattern recognition methods (support vector machine, cluster analysis and principal component analysis) to distinguish regulatory regions from coding and non-coding non regulatory DNA sequences. Using a new feature representation (the degree by which motifs are overand under-represented) we demonstrate the remarkable power of this methodology in identifying regulatory regions of Drosophila melanogaster.

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تاریخ انتشار 2008